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which gland secretes melatonin

which gland secretes melatonin

which gland secetes melatonin

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For being such a tiny structure, the pineal gland has a colorful and misunderstood history. It’s considered a somewhat mysterious organ, as its function was discovered last of the endocrine glands.
The pineal gland was once dubbed the “third eye,” which originated for many reasons, ranging from its location deep in the center of the brain to its connection to light. Also, the French philosopher and mathematician René Descartes was fascinated with the pineal gland. He even regarded it as the “principal seat of the soul, and the place in which all our thoughts are formed.” However, his observations have been widely rejected1.

And while researchers are still learning about the full purpose of the pineal gland, they believe it most likely concerns melatonin—the only hormone that the gland is known to produce and release.

which gland secretes melatonin
which gland secretes melatonin

Pineal Gland Essentials

  • Of the endocrine organs, the function of the pineal gland was the last discovered.
  • Located deep in the center of the brain, the pineal gland was once known as the “third eye.”
  • The pineal gland produces melatonin, which helps maintain circadian rhythm and regulate reproductive hormones.
Anatomy of the Pineal Gland
Located near the center of the brain, the pineal gland is a very small organ shaped like a pine cone charls  (which is where it gets its name). It’s reddish-gray and about 1/3 inch long. Pineal cells and neuroglial cells (which support the pineal cells) mainly comprise the gland.
The pineal gland often appears calcified in x-rays, which is usually due to fluoride, calcium, and phosphorus deposits that build up with age.

Melatonin: The Pineal Gland Hormone
The pineal gland secretes a single hormone—melatonin (not to be confused with the pigment melanin). This simple hormone is special because its secretion is dictated by light. Researchers have determined that melatonin has two primary functions in humans—to help control your circadian (or biological) rhythm and regulate certain reproductive hormones.
Circadian Rhythm
Your circadian rhythm is a 24-hour biological cycle characterized by sleep-wake patterns. Daylight and darkness help dictate your circadian rhythm. Light exposure stops the release of melatonin, and in turn, this helps control your circadian rhythms.
Melatonin secretion is low during the daylight hours and high during dark periods, which has some influence over your reaction to photoperiod (the length of day versus night). Naturally, photoperiod affects sleep patterns, but melatonin’s degree of impact over sleep patterns is disputed.
which gland secretes melatonin
Day  melatonin, Night  melatonin. Produces sleepiness.
Melatonin blocks the secretion of gonadotropins (luteinizing hormone and follicle stimulating hormone) from the anterior pituitary gland. These hormones aid in the proper development and functioning of the ovaries and testes.

The pineal gland’s full purpose is still a bit of a mystery. But research suggests that we’re getting closer to understanding the pineal gland—and more about the endocrine system as a whole.

The Pineal Gland and Melatonin

The pineal gland or epiphysis synthesizes and secretes melatonin, a structurally simple hormone that communicates information about environmental lighting to various parts of the body. Ultimately, melatonin has the ability to entrain biological rhythms and has important effects on reproductive function of many animals. The light-transducing ability of the pineal gland has led some to call the pineal the “third eye”.


Anatomy of the Pineal Gland

The pineal gland is a small organ shaped like a pine cone (hence its name). It is located on the midline, attached to the posterior end of the roof of the third ventricle in the brain. The pineal varies in size among species; in humans it is roughly 1 cm in length, whereas in dogs it is only about 1 mm long. To observe the pineal, reflect the cerebral hemispheres laterally and look for a small grayish bump in front of the cerebellum. The images below shows the pineal gland of a horse in relation to the brain.

Histologically, the pineal is composed of “pinealocytes” and glial cells. In older animals, the pineal often is contains calcium deposits (“brain sand”).

How does the retina transmit information about light-dark exposure to the pineal gland? Light exposure to the retina is first relayed to the suprachiasmatic nucleus of the hypothalamus, an area of the brain well known to coordinate biological clock signals. Fibers from the hypothalamus descend to the spinal cord and ultimately project to the superior cervical ganglia, from which post-ganglionic neurons ascend back to the pineal gland. Thus, the pineal is similar to the adrenal medulla in the sense that it transduces signals from the sympathetic nervous system into a hormonal signal.

which gland secretes melatonin
which gland secretes melatonin

Melatonin: Synthesis, Secretion and Receptors

The precursor to melatonin is serotonin, a neurotransmitter that itself is derived from the amino acid tryptophan. Within the pineal gland, serotonin is acetylated and then methylated to yield melatonin.

Synthesis and secretion of melatonin is dramatically affected by light exposure to the eyes. The fundamental pattern observed is that serum concentrations of melatonin are low during the daylight hours, and increase to a peak during the dark.

Two melatonin receptors have been identified from mammals
 (designated Mel1A and Mel1B) that are differentially expressed in different tissues and probably participate in implementing differing biologic effects. These are G protein-coupled cell surface receptors. The highest density of receptors has been found in the suprachiasmatic nucleus of the hypothalamus, the anterior pituitary (predominantly pars tuberalis) and the retina. Receptors are also found in several other areas of the brain.The mechanism behind this pattern of secretion during the dark cycle is that activity of the rate-limiting enzyme in melatonin synthesis – serotonin N-acetyltransferase (NAT) – is low during daylight and peaks during the dark phase.

In some species, circadian changes in NAT activity are tightly correlated with transcription of the NAT messenger RNA, while in other species, post-transcriptional regulation of NAT activity is responsible. Activity of the other enzyme involved in synthesis of melatonin from serotonin – the methyltransferase – does not show regulation by pattern of light exposure.

Melatonin is synthesized not only in the pineal gland, but in a broad range of other tissues. It is also present in all microorganisms, animals and plants, consumption of which additional sources of melatonin.

Biological Effects of Melatonin

Melatonin has important effects in integrating photoperiod and affecting circadian rhythms. Consequently, it has been reported to have significant effects on reproduction, sleep-wake cycles and other phenomena showing circadian rhythm.

which gland secretes melatonin
which gland secretes melatonin

Effects on Reproductive Function

Seasonal changes in daylength have profound effects on reproduction in many species, and melatonin is a key player in controlling such events. In temperate climates, animals like hamsters, horses and sheep have distinct breeding season. During the non-breeding season, the gonads become inactive (e.g males fail to produce sperm in any number), but as the breeding season approaches, the gonads must be rejuvenated. Photoperiod – the length of day vs night – is the most important cue allowing animals to determine which season it is. As you’ve probably deduced by now, the pineal gland is able to measure daylength and adjust secretion of melatonin accordingly. A hamster without a pineal gland or with a lesion that prevents the pineal from receiving photoinformation is not able to prepare for the breeding season.

The effect of melatonin on reproductive systems can be summarized by saying that it is anti-gonadotropic. In other words, melatonin inhibits the secretion of the gonadotropic hormones luteinizing hormone and follicle stimulating hormone from the anterior pituitary. Much of this inhibitory effect seems due to inhibition of gonadotropin-releasing hormone from the hypothalamus, which is necessary for secretion of the anterior pituitary hormones.

One practical application of melatonin’s role in controlling seasonal reproduction is its use to artificially manipulate cycles in seasonal breeders. For example, sheep that normally breed only once per year can be induced to have two breeding seasons by treatment with melatonin.

Effects on Sleep and Activity

Melatonin is probably not a major regulator of normal sleep patterns, but undoubtedly has some effect. One topic that has generated a large amount of interest is using melatonin alone, or in combination with phototherapy, to treat sleep disorders. There is some indication that melatonin levels are lower in elderly insomniacs relative to age matched non-insomniacs, and melatonin therapy in such cases appears modestly beneficial in correcting the problem.

Another sleep disorder is seen in shift workers, who often find it difficult to adjust to working at night and sleeping during the day. The utility of melatonin therapy to aleviate this problem is equivocal and appears not to be as effective as phototherapy. Still another condition involving disruption of circadian rhythms is jet lag. In this case, it has repeatedly been demonstrated that taking melatonin close to the target bedtime of the destination can alleviate symptoms; it has the greatest beneficial effect when jet lag is predicted to be worst (e.g. crossing many time zones).

In various species, including humans, administration of melatonin has been shown to decrease motor activity, induce fatigue and lower body temperature, particularly at high doses. The effect on body temperature may play a significant role in melatonin’s ability to entrain sleep-wake cycles, as in patients with jet lag.

Other Effects of Melatonin

One of the first experiments conducted to elucidate the function of the pineal, extracts of pineal glands from cattle were added to water containing tadpoles. Interestingly, the tadpoles responded by becoming very light in color or almost transparent due to alterations in melanin pigment distribution. Although such cutaneous effects of melatonin are seen in a variety of “lower species”, the hormone does not have such effects in mammals or birds.

Melatonin Supplementation

Melatonin is readily absorbed after consumption and dietary supplements containing melatonin are useful in some circumstances, including adult sleep disorders and jet lag. Additionally, there is increasing evidence that melatonin protects against a variety of cardiovascular diseases and that supplementation, especially in the elderly, who have decreased endogenous synthesis, may be useful as a cardioprotective. Some caution is required – there have been instances of children becoming ill after consumption of melatonin gummies candy.

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