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can i take naproxen with tylenol

can i take naproxen with tylenol

can i take naproxen with tylenol?

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can i take naproxen with tylenol?

Yes, Aleve (naproxen) and Tylenol are generally safe to take at the same time. However, taking them at different times is often more effective.

A person could start, for example, by taking Tylenol in the morning. The pain may return before the next scheduled dose, depending on the strength of the Tylenol. At the first sign of pain, a person could take Aleve and continue to alternate the two as necessary.

Staggering the medications can help to extend the relief from pain.

If instead, a person takes both at the same time, the combined pain relief may wear off before it is safe to take the next doses.

There are other ways to alternate the medications effectively.

For example, a person may take either Tylenol or Aleve every day to help control aches and pains from arthritis. If new pain arises, they could take the other drug as needed.

Or, if the pain is severe, taking regular doses of Tylenol may not provide relief. A person may decide to add regular doses of Aleve. The combination may work better than either drug alone.

can i take naproxen with tylenol
can i take naproxen with tylenol

How they work?

Both naproxen and acetaminophen help reduce fever and relieve mild to moderate pain. Examples of these types of pain include:

  • sore throats
  • headaches
  • body or muscle aches
  • menstrual cramps
  • arthritis
  • toothaches

The drugs do different things to relieve this pain. Naproxen blocks the formation of substances that cause inflammation. Reducing inflammation then helps to reduce pain. Acetaminophen, on the other hand, doesn’t reduce inflammation. Instead, it reduces the sensation of pain. It works by blocking the release of substances in the brain that cause pain sensation.


Healthcare professionals usually suggest starting off with the smallest dosage of a drug. If the symptoms persist, they then recommend increasing the dosage or adding another medication.

Starting off with the lowest effective dosage reduces the risk of side effects.

Doctors generally recommend taking different dosages of Aleve and Tylenol. The same is true for other drugs that contain naproxen or acetaminophen.

The recommended dosage of Aleve, for adults, is one pill every 8–12 hours. However, this depends on the strength of the medication.

A person can usually take acetaminophen-based pain relievers like Tylenol more frequently.

Tylenol generally comes in 325 milligram (mg), 500 mg, or 650 mg pills. Citing the product’s labeling, Harvard Medical School reports that a healthy adult can take Tylenol in any of the following doses:

  • 1 or 2 325 mg pills every 4–6 hours, taking no more than 8–10 pills per day

1 or 2 650 mg extended release pills every 8 hours, taking no more than 4–6 pills per day


The biggest consideration when taking acetaminophen is the possibility of overdose. Acetaminophen is a common ingredient in many different over-the-counter products, so it can be easy to take too much without even realizing it.

An acetaminophen overdose can cause serious liver damage. To avoid this, you should understand your limit for acetaminophen. Generally, people shouldn’t have more than 3 g of acetaminophen per day. You can talk to your doctor to find out the specific limit that’s right for you. Then, keep track of how much acetaminophen you take by reading all medication labels. It’s often best to use only one medication that contains acetaminophen at a time.

Tylenol, Panadol, Tempra (and also an ingredient in Excedrin)

  • How it works. Acetaminophen is not an NSAID. Experts aren’t actually sure how it works, but it seems to affect chemicals that increase the feeling of pain.
  • Benefits. Acetaminophen reduces pain and lowers fevers. Experts believe that acetaminophen is safe for people with high blood pressure.Acetaminophen is also less likely to cause gastrointestinal problems than NSAIDs. It is safe for women who are pregnant and nursing.
  • Side effects and risks. Experts believe that acetaminophen is safe for people with high blood pressure. Very high doses of acetaminophen can cause serious liver damage. Long-term use of acetaminophen in high doses — especially when combined with caffeine (Excedrin) or codeine (Tylenol with codeine) can cause kidney disease.Acetaminophen doesn’t reduce swelling, like aspirin and other NSAIDs do. It may be less helpful in treating pain that’s caused by inflammation, such as some types of arthritis.
can i take naproxen with tylenol
can i take naproxen with tylenol

How does acetaminophen work?

Acetaminophen relieves pain and fever by reducing the production of prostaglandins. If your pain is not due to inflammation or swelling, acetaminophen is fine to use.

Acetaminophen is one of the most common drug ingredients, found in hundreds of prescription and over-the-counter (OTC) medications. Here’s a list of common OTC products used for pain relief that contain acetaminophen.

  • Actifed
  • Coricidin
  • DayQuil
  • Dimetapp
  • Excedrin
  • Midol
  • NyQuil
  • Tylenol

Side effects of acetaminophen

  • Nausea
  • Headache or lightheadedness
  • Trouble urinating
  • Dark stool
  • Itching

Rare but serious adverse events of ibuprofen and acetaminophen include allergic reactions (rash, hives, swelling), hoarseness, difficulty breathing or swallowing, and chest pain. Too much ibuprofen can cause gastrointestinal bleeding, and it can worsen stomach ulcers. Liver damage may occur in the overuse of acetaminophen. These symptoms require medical attention. You should call 911 or seek out an emergency department as soon as possible.

How much acetaminophen can I take?

The dosing recommendation for acetaminophen depends on the strength of the pill. For the 325 mg pills, you can take up to 2 pills every 6 hours. For the 500 mg pills (extra-strength tablets), you can take up to 2 pills every 8 hours (or twice a day).

The highest dose of acetaminophen you should ever take (not that you should try), is 4 grams per day. That would be 8 extra-strength Tylenol tablets (500 mg each) or 12 regular-strength tablets (325 mg each). Don’t take more than that.

can i take naproxen with tylenol
can i take naproxen with tylenol

What is naproxen?

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.

Naproxen is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps. It can also be used to treat acute pain caused by other conditions not listed in this medication guide.

The delayed-release or extended-release tablets are slower-acting forms of naproxen that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms will not work fast enough to treat acute pain.

Naproxen (Aleve)

  • Provides pain relief
  • Works as an anti-inflammatory
  • Longer-acting than acetaminophen and ibuprofen
  • Available over the counter in pill form; by prescription in liquid form
  • May not be used in children with gastrointestinal or  kidney abnormalities or with medications affecting kidney function
  • Needs to be taken with food or milk
  • May not be used 72 hours prior to surgery
  • May not be used in patients under 2 years old

Side Effects

Upset stomach, nausea, heartburn, headache, drowsiness, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, difficult/painful swallowing, hearing changes (such as ringing in the ears), mental/mood changes, signs of kidney problems (such as change in the amount of urine), unexplained stiff neck, vision changes, symptoms of heart failure (such as swelling ankles/feet, unusual tiredness, unusual/sudden weight gain).

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

can i take naproxen with tylenol
can i take naproxen with tylenol

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, extreme drowsiness, seizures.

Talk to your doctor

Neither naproxen or acetaminophen should be taken for longer than 10 days to treat pain, and neither drug should be taken for longer than three days to treat fever. Taking either drug for longer than recommended or at doses higher than recommended may increase your risk of side effects. However, taking them together is generally safe.

Pain or fever that hasn’t improved may be a sign of a condition that requires a different treatment. If your fever lasts for longer than three days, contact your doctor.

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